ISAAC Resources - ISAAC Phase Four

ISAAC Phase Four is the development and expansion of the scope of the ISAAC website and the creation of this resources section for ISAAC collaborators especially those in low and middle income countries. Management guidelines and other resources will be listed here. Management guidelines which appear on this website are free of pharmaceutical industry sponsorship.

Do you know of any such guidelines?

More guidelines for children which were not sponsored by the pharmaceutical industry will be added to the ISAAC website as they become available. If you know of any such guidelines please contact Eamon Ellwood.

General Resources

European Respiratory Monograph

The European Respiratory Society (ERS) has recently published the Paediatric Asthma issue of its quarterly book series, the European Respiratory Monograph (ERM). The issue is Guest Edited by leaders in the field Professor Kai-Håkon Carlsen and Professor Jorrit Gerritsen, who have brought together distinguished pulmonologists to provide a comprehensive review of paediatric asthma. All aspects of paediatric asthma are covered, from birth to the start of adulthood, and the issue includes chapters on: asthma phenotypes; physical exercise; food allergy and anaphylaxis; genetics and epigenetics; pollution; asthma treatment; and psychological factors. This issue of the ERM book series should prove a useful resource in daily clinical practice, and it is hoped that young pulmonologists in particular will find this a source of inspiration in their future work.

ERS members can freely access the Paediatric Asthma issue online at To purchase a print copy of the issue or to find out more about the ERM, contact

Global Asthma Report 2014

The Global Asthma Report 2014 includes strategic and practical recommendations and valuable information for governments, health organisations, health professionals, and people with asthma including: Latest Asthma Research; Maps and data on the global prevalence; Economic burden of asthma; Success stories; Key recommendations.

Download report | View website | Download press release | Download Press Release Presentation

Global Asthma Report 2011

ISAAC has collaborated with The Union to produce the Global Asthma Report 2011.This report shows the tools to manage asthma exist but are not reaching many of the 235 million people affected. The Global Asthma Report 2011 highlights the issues surrounding this major non-communicable disease.
Designed for stakeholders from government ministers and policy-makers to health workers and people with asthma, the Global Asthma Report 2011 is a richly illustrated "atlas" that provides an overview of what is known about the causes and triggers of the disease, the global prevalence, the progress being made and the significant challenges today and for the future.
Download report | View website

Lectures by ISAAC Steering Committee members

ISAAC 20 Year Anniversary Symposium - Auckland 2011

The ISAAC 20 Year Anniversary Symposium was held in the Fisher and Paykel Auditorium, Owen G Glenn Building, The University of Auckland on Thursday 27th of January 2011
News article

The Symposium was hosted by The University of Auckland and Massey University, and officially opened by Hon. Tariana Turia, Associate Minister of Health. Lectures of ISAAC findings in various aspects of allergic diseases were given by members of the ISAAC Steering Committee. Pdf files of these presentations are now available for download here.

Auckland Medical Research Foundation Public Lecture:
Asthma and allergies: Where in the world are we now?

Professor Innes Asher shared the highlights of the ISAAC work and recent Symposium at this public lecture hosted by the Auckland Medical Research Foundation. In this lecture Professor Asher highlighted the changes in thinking about asthma and allergies over the last 20 years.
download slides | view presentation

Auckland Starship Childrens Hospital Paediatric Update

Auckland Starship Childrens Hospital Paediatric Update October 2010. View Professor Innes Asher’s presentation on ‘Asthma and allergies - where in the world have we got to? ISAAC from 1991 to 2010’.
View Presentation

ATS Conference New Orleans 2010

American Thoracic Society International Conference in New Orleans May 2010. View Professor Innes Asher’s presentation on ‘Asthma Disparities: a Global View’.
download notes

ISAAC Symposium - Mérida 2009

The ISAAC symposium was held in the Manuel Cepeda Peraza Auditorium in the Central Building of the Autonomous University of Yucatan (Universidad Autónoma de Yucatán) on Saturday 28th of November 2009
News article from University of Yucatan

The Symposium was hosted by Professor Manuel Baeza Bacab, the ISAAC National Co-ordinator for Mexico, and officially opened by the Director of the university, Alfredo Dájer Abimerhi, MVZ M. Phil. Lectures of ISAAC findings in various aspects of allergic diseases were given by 6 members of the ISAAC Steering Committee. Pdf files of these presentations can be downloaded below.

Allergy, Genetics and Environment.
Alergia, Genética y Ambiente.
Professor Neil Pearce

World-Wide Map of the Prevalence of Rinoconjunctivitis in Children.
Mapa Mundial de la prevalencia de Rinoconjunctivitis en Niños.
Professor Luis García-Marcos

Asthma in Latin America.
Asma en América Latina.
Professor Javier Mallol
Coming soon

Global Epidemiology of Allergic Diseases.
Epidemiología Global de las Enfermedades Alérgicas.
Professor Innes Asher

Atopic Eczema.
Eccema Atópico.
Professor Hywel Williams

Hygiene: Relationship between Allergic Diseases and

Higiene: Relación entre Enfermedades Alérgicas e Infección.
Professor David Strachan

Asthma - Indigenous Resources

Maori Asthma Review (1991)
Maori Asthma Review Update (2000)

Asthma management interventions

Asthma management intervention and evaluation in a developing country

Sunia Foliaki, Toakase Fakakovikaetau, Wendyl D'Souza, Sione Latu, Viliami Tutone, Soo Cheng, Neil Pearce. Reduction in asthma morbidity following a community-based asthma self-management programme in Tonga. International Journal of Tuberculosis and Lung Disease 2008; 13(1):142–147. Contact: Dr Sunia Foliaki

Eczema Resources

DermNet NZ

DermNet NZ was established by the New Zealand Dermatological Society, the national association of New Zealand registered dermatologists, to provide information about skin diseases, conditions and treatment for patients and their health professionals.

Skin Examination Manual

This Manual produced by Prof. Hywel C. Williams at the Centre of Evidence Based Dermatology in Nottingham, UK, is designed to aid in examining study participants physically for flexural eczema. It consists of an online set of training images and a quality control test for fieldworkers to ensure standardisation of study methods. It can be found at:

Eczema resources at NHS Evidence

Each year NHS Evidence – skin disorders undertakes an annual evidence update on atopic eczema. The update includes new guidelines and new systematic reviews published in the preceding year, and involves a detailed commentary of the clinical implications of the new evidence by Hywel Williams and other colleagues

Overview of systematic reviews of eczema prevention

Michelle Foisy, Robert J. Boyle, Joanne R. Chalmers, Eric L. Simpson, Hywel C. Williams. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews Evidence-Based Child Health: A Cochrane Review Journal Volume 6, Issue 5, pages 1322–1339, September 2011

GREAT database

The Global Resource for Eczema Trials (GREAT) is an international collection of all randomized controlled trials published since the year 2000 that is free for anyone to use.

Patient Oriented Eczema Measure (POEM)

A quick instrument to measure those aspects about eczema severity that matter to patients

Eczema clinic record sheet

– for use in a clinical setting to be filled in by parents before consultation

Harmonising Outcome Measures for Eczema

The Harmonising Outcome Measures for Eczema project is all about trying to reduce the current long list of outcome measures used in eczema clinical trials to 3 or 4 measures that all future trials can use. Many of the previous scoring systems for eczema have never been validated properly, and it is almost impossible to make any sense of the trial evidence base since different studies have used different outcomes. The HOME project hopes to come up with a list of core outcome measures that should be measured in all future eczema trials.
HOME Website (

Scientific American April 2011: why-are-asthma-rates-soaring

Asthma Drug Facility (ADF)

The Asthma Drug Facility provides affordable access for low and middle income countries to quality assured essential asthma drugs. It was established by the International Union Against Tuberculosis and Lung Disease (IUATLD) with the support of partners such as the World Health Organization (WHO). In addition to the lower the cost of essential asthma medicines, ADF offers technical assistance and support and a strategy for management of asthma to medical practitioners in low and middle income countries.
ADF Website (

Asthma Foundation of New Zealand

The Asthma Foundation of New Zealand is New Zealand’s not-for-profit sector authority on asthma and other respiratory illnesses

The International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes [EISL]) English | Spanish

EISL is an international cross-sectional multi-centre study designed to assess the prevalence, severity and other factors related to infant wheezing during the first year of life in Latin America and the Iberian Peninsula. EISL has Spanish and English language web sites.

Nomenclature of Allergic Disease, World Allergy Organisation (WAO)

The report of the WAO Nomenclature Review Committee, updating the EAACI Nomenclature Position Statement published in 2001, was published in the Journal of Allergy and Clinical Immunology in May 2004 (J Allergy Clin Immunol 2004; 113: 832-6). The aim of the report is to present a globally acceptable nomenclature for allergic diseases, with the ultimate goal of improving communication in the field of allergy. The nomenclature can be used independently of target organ or patient age group, and is based on the mechanisms which initiate and mediate allergic reactions. As knowledge about basic causes and mechanisms continues to improve, the nomenclature will be reviewed and updated on a triennial basis. This web page includes a summary of the terminology in 23 languages.

Data Analysis

Below are links to some useful articles on ISAAC Data entry and Data analysis written by members of the ISAAC International Data Centre. These articles were published in the bi-annual ISAAC newsletter.

Analysis of ISAAC Phase Three Study Survey Data from One Centre. ISAAC Newsletter December 2001

Analysis of ISAAC Phase Three Study Survey Data from One Centre (Part 2). ISAAC Newsletter April 2002

Phase Three Data Entry. ISAAC Newsletter April 2002

ISAAC Phase Three Data Entry - Part2: Epi-Info - Important features you may need to know ISAAC Newsletter July 2002

Funding of ISAAC Phase Four

ISAAC Phase Four has received funding from the Hawke’s Bay Medical Research Foundation and The University of Auckland, New Zealand