Local Publications

The following publications used ISAAC data from the Bilbao centre:

  • González Díaz C, Sánchez González E, García-Marcos L, Morato Rodríguez MD, Molina Zelaia I, Burgaleta Sagaseta A, Zaballa Gorordo J, Delgado Rubio A. Prevalence and severity of asthma in 13-14-year-old children in Bilbao.[Spanish]. An Esp Pediatr.1998; 48(6): 608-14.
  • Morales Suárez-Varela MM, García-Marcos AL, González DC, et al. Prevalence of atopic eczema and nutritional factors in 6-7 year old children.[article in spanish]. Aten Primaria 2007; 39(7):355-360.
  • Arnedo-Pena A, García-Marcos L, Fernández-Espinar JF, Bercedo-Sanz A, Aguinaga-Ontoso I, González-Díaz C, Carvajal-Urueña I, Busquet-Monge R, Suárez-Varela MM, de Andoín NG, Batlles-Garrido J, Blanco-Quirós A, López-Silvarrey Varela A, García-Hernández G. Sunny hours and variations in the prevalence of asthma in schoolchildren according to the International Study of Asthma and Allergies (ISAAC) Phase III in Spain. Int J Biometeorol 2011; 55(3): 423-434

Bilbao Centre

Phase OnePhase TwoPhase Three View Centre Details
Centre:Bilbao, Spain ( Western Europe )
Principal Investigator:Dr Alfonso Delgado Rubio
Age Groups:13-14, 6-7Timeframe:February 1994 to November 1994
Sampling Frame:
Phase OneView Centre DetailsPhase TwoPhase Three
Centre:Bilbao, Spain ( Western Europe )
Principal Investigator:Dr Carlos González Díaz
Age Groups:13-14, 6-7Timeframe:November 2001 to March 2002
Sampling Frame:All schools in Bilbao city district area (Spain). The same sampling frame was used for both Phase One and Phase Three.


Dr Carlos González Díaz

Dr Carlos González Díaz

Pediatric Allergy Unit
Department of Pediatrics
Hospital de Basurto


  • Phase Three Principal Investigator for Bilbao

Dr Alfonso Delgado Rubio

Urgencias de Pediatria. Pabellon Makua
Hospital de Basurto
Avda Montevideo, 18



  • Phase One Principal Investigator for Bilbao
  • Phase Three collaborator for Bilbao

In 1994, the ISAAC project was started in Spain, launched by our national coordinator, Prof. Luis Garcia Marcos. At the beginning, eight centers constituted the Phase One, and ISAAC Bilbao center was led until 1998 by Prof. Alfonso Delgado. Since 1998, I have been the principal investigator and responsible for the Phases One and Three.

The results of this Project, apart from the multiple articles that have been published, have allowed me to defend my doctoral thesis entitled ‘’Prevalence and severity of asthma in 13-14 years old children living in Bilbao “ in February of 1997 with the highest grade.

It highlighted that the prevalence of asthma in our center had increased in Phase Three relative to Phase One, both in children aged 6-7 years (6.9% vs 12.2%) and in children 13-14 years (11.9% vs 12.8%)

I would like to thank all people who at some point belonged to the Bilbao ISAAC Centre in any of its phases without them it would have not be possible to perform this work:Those people are : Prof Alfonso Delgado, Dr. Andres Gonzalez, Dra. Elena Sanchez, Dra. Nelida Garcia, Dra Marga Ferrer, Dr Javier Zaballa, and Dra Nekane Morato,