Local Publications
The following publications used ISAAC data from the Hawkes Bay centre:
- Erwin EA, Wickens K, Custis NJ, Siebers R, Woodfolk J, Barry D, Crane J, Platts-Mills TA. Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens. J Allergy Clin Immunol 2005; 115(1): 74-9.
- Wickens K, Barry D, Friezema A, Rhodius R, Bone N, Purdie G, Crane J. Fast foods - are they a risk factor for asthma?. Allergy 2005; 60(12): 1537-41.
- Wickens K, Barry D, Friezema A, Rhodius R, Bone N, Purdie G, Crane J. Obesity and asthma in 11-12 year old New Zealand children in 1989 and 2000. Thorax 2005; 60(1): 7-12.
- Wickens K, Crane J, Kemp T, Lewis S, D'Souza W, Sawyer G, Stone L, Tohill S, Kennedy J, Slater T, Rains N, Pearce N. A case-control study of risk factors for asthma in New Zealand children. Aust N Z J Pub Health.2001;25(1):44-9.
- Wickens K, Pearce N, Siebers R, Ellis I, Patchett K, Sawyer G, Stone L, Tohill S, Kennedy J, Slater T, Lewis S, Fitzharris P, Crane J. Indoor environment, atopy and the risk of the asthma in children in New Zealand. Pediatr Allergy Immunol.1999 Aug;10(3):199-208.
Hawkes Bay Centre
| Phase One View Centre Details | Phase Two | Phase Three | |||
| Centre: | Hawkes Bay, New Zealand ( Oceania ) | ||||
| Principal Investigator: | Professor Julian Crane | ||||
| Age Groups: | 10.1-12.6 years, | Timeframe: | February 2000 to June 2000. | ||
| Sampling Frame: | All schools within the municipalities of Hastings and Havelock North. | ||||
Personnel
Dr David Barry
Paediatrician
Hawke's Bay Regional Hospital
Private Bag 9014
New Zealand
Roles:
- Phase One Principal Investigator for Hawkes Bay
- Phase Two collaborator for Hawkes Bay
Professor Julian Crane
Wellington Asthma Research Group
Wellington School of Medicine, University of Otago Wellington
P O Box 7343
Wellington South
New Zealand
Roles:
- ISAAC Steering Committee
- Phase Two Principal Investigator for Hawkes Bay
Dr Kristin Wickens
WARG
Wellington School of Medicine
P O Box 7343
New Zealand
Roles:
- Phase Two collaborator for Hawkes Bay
Phase Two in Hawke's Bay
We chose to undertake ISAAC Phase Two study in Hawke’s Bay because it gave us an opportunity to undertake two studies using largely a single set of fieldwork, to provide data for ISAAC Phase Two and secondly we were able to use much of the same data to provide to repeat one of the first international asthma prevalence surveys that had been undertaken by Michael Burr and David Barry in the Hawke’s Bay and Wales[Barry 1991], and later included South Africa and Sweden[Burr 1994], using the same schools, methodology and personnel to give us a comparison of prevalence over a 10 year period.
The study was run by Dr Kristin Wickens in the Hawkes Bay over the summer period 2000. We had excellent help from Dr Barry himself and also from one of his retired senior paediatric nurses – Ms Ngaire Bone. We were also fortunate to have two third year medical students join us from the Netherlands looking for a small student elective to undertake research and they provided excellent additional support for the field work and also got a publication from an add on project undertaking during the fieldwork[Rhodius 2002]. The study provided New Zealand data for ISAAC Phase Two, but also provided a number of spin-off studies that looked at fast foods and asthma and changes in obesity and their relationship to asthma over 10 years[Wickens 2005(1), Wickens 2005(2)]. The data also formed the basis for some interesting work on cat allergen[Erwin 2005] undertaken by Tom Platt-Mills and colleagues who also measured spIgE levels for the study.
The Hawkes Bay turned out to be an excellent place to undertake research like this and we had tremendous co-operation from the schools and from the surrounding community and also had enormous benefit from employing people who were well known in the community and were able to encourage both schools and parents to take part.
Also we undertook two forms of measurement of airway hyperresponsiveness, exercise and hypertonic saline. The exercise challenge used a five minute running test[Burr 1989] allowing us to compare this challenge with previous studies and with the UK centre which also used it. We also undertook a hypertonic saline challenge and again were fortunate to have a visiting research fellow to help us with this.
In this 8 to 12 age group we found the prevalence of wheezing in the last year was 22.0% and asthma ever, 35.7%. A positive exercise challenge (≥15% fall in PEFR post exercise) was found in 8.4%. A positive skin prick test to any allergen was found in 34.7% of children. Interestingly when comparing the prevalence from 10 years before (restricted to just the 12 year old children) wheezing had increased from 17.7% to 23.3%, asthma ever from 16.9% to 37%, while a positive exercise response had fallen from 12.3% to 9.0%.
References
- Barry DM, Burr ML, Limb ES. Prevalence of asthma among 12 year old children in New Zealand and South Wales: a comparative survey. Thorax. 1991;46(6):405-9.
- Burr M, Limb E, Andrae S, Barry D, Nagel F. Childhood asthma in four countries: A comparative survey. Int J Epid. 1994;23(2):341-7.
- Rhodius R, Wickens K, Cheng S, Crane J. A comparison of skin test methodologies and allergens from two different manufacturers. Ann Allergy Asthma and Immunol. 2002;88:374-9.
- Wickens K, Barry D, Friezema A, Rhodius R, Bone N, Purdie G, Crane J. Fast foods are they a risk factor for asthma. Allergy. 2005;60:1537-41.
- Wickens K, Barry D, Friezema A, Rhodius R, Bone N, Purdie G, Crane J. Obesity and asthma in 11-12 year old New Zealand children in 1989 and 2000. Thorax. 2005;60:7-12.
- Erwin E, Wickens K, Custis N, Siebers R, Woodfolk J, Barry D, Crane J, Platts-Mills T. Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens. J Allergy Clin Immunol. 2005;115:74-9.
- Burr ML, Butland BK, King S, Vaughan WE. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child. 1989;64(10):1452-6.
