ISAAC Diary
ISAAC Timeline Milestones
Year |
Month |
Phase One |
Phase Two |
Phase Three |
Other |
World/Other events |
1989 |
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Fall of Berlin wall |
1990 |
Dec |
6-7 yr and 13-14 yr age gps decided. Core methods: written questionnaire on asthma, rhinitis and eczema. |
Idea of lung function in 9-10 yr olds |
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First meeting |
ECRHS began |
1991 |
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Name of The International Study on Asthma and Allergies in Childhood (ISAAC) suggested by Bonnie Sibbald in a London café, and adopted by the founders |
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March |
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Ulrich Keil, Neil Pearce and Innes Asher meet in Auckland. Merged the German and New Zealand initiatives |
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Aug |
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First website put online at CERN (the first webpage had been developed several months earlier) |
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Dec |
Aims, written and video questionnaires agreed |
Phase Two modules concept agreed. Develop modules for BHR, serum IgE, skin prick tests, skin examination, medications & health services. |
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Dissolution of Soviet union |
1992 |
Dec |
ISAAC Phase One Manual printed |
Further development of modules for BHR, serum IgE, skin prick tests, skin examination, medications & health services, risk factors indoor and outdoor, other respiratory symptoms |
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1993 |
April |
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First ISAAC newsletter |
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August |
Phase One coding and data transfer manual printed |
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Oct |
European Paediatric Asthma Study (EPAS) will join ISAAC |
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Nov |
Pilot study published in ERJ |
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Dec |
Second edition of Phase One manual printed |
ISAAC satellite workshop on the airway reactivity module in Auckland, New Zealand |
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1994 |
Oct |
42 Countries 107 centres recruited, collecting data |
Decided age group 9-11 yr olds Modules on blood spots, aeroallergen measurement Structure for Phase Two decided. David Strachan Chair of Phase Two implementation committee |
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1995 |
March |
Phase One rationale and methods paper published in ERJ |
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Sept |
Data received from 36 centres in 18 countries ISAAC at ERS – Erika von Mutius gave a presentation 20 Sept 1995 |
Phase Two centres to be identified by 1996 |
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Dec |
Data received in Auckland from 110 centres |
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1996 |
Sept |
Centre report developed |
Confirmed hypertonic saline for BHR |
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ISAAC session at ERS
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1997 |
Sept |
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Domain name google.com registered |
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Sept |
Data from 48 additional centres received |
Munster and Munich will coordinate Phase Two. Stephan Weiland will be the contact person |
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Nov |
First Phase One worldwide paper published |
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ECRHS2 began |
1998 |
May |
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ISAAC Phase Two Manual printed |
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ISAAC website being developed |
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Sept |
Several ecological analysis papers drafted |
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Phase Three is to assess trends in prevalence |
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1999 |
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First publication describing low prevalence of allergy among children of farmers (Braun-Fahrländer) |
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Jan |
First 4 Phase One worldwide papers published |
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March |
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Phase Two training seminar in Münster |
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Oct |
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At least 1000 subjects |
Grant received from Glaxo Wellcome |
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2000 |
July |
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ISAAC Phase Three Manual printed |
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Sept |
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$NZ500,000 received from GlaxoWellcome for Phase Three |
Comparison with ECRHS published |
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Oct |
Decision to put ISAAC Phase One summary data on website |
Genetic analyses to be discussed |
Environmental questionnaire piloted. |
ISAAC letterhead with names of all Steering Committee |
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2001 |
Feb |
First Ecological analysis paper published |
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Sept |
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EU funding for 15 centres in Europe |
EOI 226 centres from 99 countries (91 new centres) |
ISAAC will continue beyond Phases Two and three |
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2002 |
Sept |
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Phase Two Steering Group formed Data centre moved to Ulm |
226 registrations from 89 countries |
Principle of ‘no survey without service’ – principle for Phase Four |
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Nov 2002—Jul 2003 |
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Severe acute respiratory syndrome (SARS) pandemic. 774 deaths among 8096 cases. |
2003 |
Nov |
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226 registrations from 89 countries |
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2004 |
Sept |
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Phase Two rationale and methods paper published in ERJ |
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ISAAC symposium at ERS Glasgow, with ECRHS |
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Nov |
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30 centres in 22 countries had completed Phase Two |
286 registrations from 107 countries |
Phase Four will be an interventions study Proceed with plans for Phase Five 2010—2012 |
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2005 |
Jan |
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Phase Three rationale and methods paper published in Int J Tuberc Lung Dis |
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Oct |
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Nobel Prize for Physiology or Medicine awarded jointly to Robin Warren and Barry Marshall for discovery of Helicobacter pylori infection as a cause of peptic ulceration |
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Nov |
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Data centre will not accept any more centres |
Link to Asthma Drug facility established |
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2006 |
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Mutations in the filaggrin gene identified as a risk factor for eczema |
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Sept |
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First time trends paper published |
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Nov |
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Phase Four is about education and advocacy |
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2007 |
19 March |
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Stephan Weiland died unexpectedly |
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June |
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First Phase Two results paper published |
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Sept |
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Tables of first EQ results compiled |
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2008 |
Jan |
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Redevelopment of ISAAC website |
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Sept |
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First EQ paper published |
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Oct |
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ISAAC Monograph will be web-based |
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2009 |
Feb |
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First world map paper published |
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June |
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H1N1 influenza ("swine flu") declared a pandemic by the WHO |
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Nov |
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ISAAC will finish in Dec 2012 if no funding for Phase Five |
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2010 |
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Last Phase One ecological worldwide analysis paper published. Total 11 publications. |
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ISAAC summary data on website |
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May |
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ATS ISAAC presentation on global disparities in asthma |
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Dec |
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ISAAC Story being written |
First EISL publications |
2011 |
Jan |
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ISAAC 20 year Symposium in Auckland |
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May |
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37th Newsletter published |
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September |
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12 publications of Phase Two world wide analyses. |
15 world wide publications to date; 4 time trends, 3 expanded worldmaps, 5 environmental analyses, 2 methodological papers, one correlation paper. |
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